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Thus, integration of both hormones into a single molecule may not only maximize the metabolic efficacy of the individual signals, but allow also specific delivery of estrogen into GLP1 receptor-expressing cells, avoiding potential undesired effects of estrogen on reproductive tissues, as shown also in our studies

For example, in cultured rat striatum and ventral mesencephalon, a 24 h exposure to polychlorinated biphenyls resulted in a decrease in both dopamine and GABA levels [103]

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